Tricyclic triazolic compounds

Composés triazoliques tricycliques

Abstract

The present invention relates to new tricyclic triazolic compounds having a high affinity for sigma-1 receptor as well as to the process for the preparation thereof, to composition comprising them and to their use as medicaments according to compounds of formula (I), Wherein R1 and R2 are as defined in the description.
La présente invention concerne de nouveaux composés triazoliques tricycliques ayant une affinité élevée pour le récepteur sigma-1 ainsi que leur procédé de préparation. L'invention concerne également une composition les comprenant et leur utilisation en tant que médicaments, les composés étant de formule (I), R1 et R2 étant tels que définis dans la description.

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Patent Citations (5)

    Publication numberPublication dateAssigneeTitle
    EP-1634873-A1March 15, 2006Laboratorios Del Dr. Esteve, S.A.Sigmarezeptor-Inhibitoren
    EP-1847542-A1October 24, 2007Laboratorios del Dr. Esteve S.A.Dérivés de spiro[benzopyran] ou de spiro[benzofuran] comme antagonistes du récepteur sigma
    EP-1849772-A1October 31, 2007Laboratorios Del Dr. Esteve, S.A.Dérivés bicyclic de Tetrahydopyrrole
    WO-2006021463-A1March 02, 2006Laboratorios Del Dr. Esteve, S.A.Inhibiteurs de récepteurs sigma
    WO-2006024517-A1March 09, 2006Glaxo Group LimitedFused tricyclic derivatives for the treatment of psychotic disorders

NO-Patent Citations (0)

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